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Benefits and Dangers of Accutane as a Powerful Anti-Acne Aid Accutane (Roaccutane) in Treatment of Acne Roaccutane or Accutane (USA), with its active ingredient isotretinoin (13-cis-retinoic acid), was launched in the early 1980s by the pharmaceutical giant Roche as an anti-acne medication. Isotretinoin is a substance related to vitamin A. Since vitamin A is essential for the structure and function of the skin, Accutane also has a similar effect and shows positive results even with strong acne.
Physiological Action of Accutane
Whenever a person suffers from acne, the increased activity of their sebaceous glands leads to a blockage of the pores, causing inflammation. This process shows itself through purulent pustules and pimples. In this situation, isotretinoin provides the upper layers of skin with extra retinoids, which, in its turn, increases the cellular growth. This stimulates the upper layers of the problematic skin to loosen and peel. As it becomes easier to peel off the epidermis, the pores in your skin do not get blocked that much, thus alleviating the impairment of the sebaceous glands. Accutane’s exact mechanism of action has not yet been completely established. It is, however, clear that suppressing the skin fat production, as well as shrinking the sebaceous glands leads to an improvement of acne symptoms. In addition, isotretinoin has anti-inflammatory effects. Its combined action gets the skin cleaner from the inside, the result of which is a finer skin appearance with fewer imperfections. The active substance degrades in the liver. Elimination of isotretinoin from the body occurs via stool and urine. Oral dosage forms of isotretinoin allow you to receive only about 25 percent of the active ingredient carried to the blood via intestinal absorption. Therefore, external application is much preferred, even though it has its limitations as well, mostly due to the effect of isotretinoin being strictly local. Only a very small number of patients take Accutane by the oral route.
Dangers of Inappropriate Use of Accutane
Anti-acne medications are usually prescribed to young people who suffer from a more or less severe form of acne. Accutane visibly reduces sebum production in the glands, preventing excessive sebum secretion. In addition, it inhibits inflammatory processes in the skin. However, in many cases, taking the drug can result in extremely dry skin that ages remarkably fast. This is considered one of the more common yet less harmful side effects. Much worse are the ways in which the drug can affect the patients’ mind. These adverse reactions range from heavy mood swings to depression and personality changes. In graver cases, these serious changes persist for many years after stopping treatment. Please make sure you study the Accutane leaflet and become familiar with the long list of possible side effects and warnings before starting therapy. It has been established that synthetic vitamin A derivatives can adversely affect such substances in the brain as serotonin and dopamine and, as a result, contribute to mental illnesses, such as depression. Your doctor should look carefully into your case before prescribing you this drug and monitor your well-being through the entire therapeutic course.
Changes in lifestyle you should consider when using Accutane
Rather than resort to strong acne medications alone, a much healthier approach suggests taking holistic measures against acne. Patients should try and restore the normal functioning of all body systems involved in the development of acne. This means that your digestive system, acid-base background, and hormone background should come back into balance. In this way, your acne will start receding gradually until the skin returns to its healthy state. Symptomatic pharmaceutical treatments often omit the actual problem. Your skin, as well as your intestine and kidneys, is an excretory organ, which removes pollutants, such as acids, toxins, etc. from the body. However, the skin only works like that when the other organs are overtaxed. A holistic anti-acne approach includes a targeted nutritional change, colon cleansing, and natural skincare to decrease the excretion of toxins through the skin.
